Harry Kane is the defending champion after he held off a long challenge from Salah to narrowly finish first in the top-flight scoring charts with 23 last season.
That was the third success for Kane, matching the total of Golden Boot triumphs held by the all-time EPL record goalscorer Alan Shearer.
This year Kane will be seeking what would be a record-equalling fourth crown.
Salah and Bruno Fernandes, who each made the podium last season, entered the campaign hoping to challenge again, while a proven Premier League scorer, Romelu Lukaku, returned to Chelsea after a prolific spell in Serie A with Inter.
Man Utd then brought Cristiano Ronaldo back to Old Trafford in a sensational return, making 2021/22 look like the most competitive Golden Boot race in years.
Former winner Jamie Vardy, Leeds striker Patrick Bamford, Everton’s Dominic Calvert-Lewin, West Ham star Michail Antonio and Aston Villa duo Ollie Watkins and Danny Ings are part of a strong contingent from outside England’s ‘big six’ teams who were rated as contenders when the season began.
Keep this page saved throughout the season as we take an in-depth look at the latest standings for the players who have the most EPL goals.
Egypt international Salah scored in the thrilling 2-2 draw at Chelsea to move on to 16 goals for the 2021/22 campaign.
That puts him well clear of Jota, who was substituted in the second half, in the goalscoring charts in England.
Jamie Vardy remains in third place with nine goals, one behind Jota.
There was an opportunity for Man Utd star Cristiano Ronaldo to move into the top three in the home game against Wolves on Monday.
After he had struck against Burnley to reach eight top-flight goals, Ronaldo was frustrated in a 1-0 defeat at Old Trafford and he therefore remains one of seven players in a share for fourth place.
Defending champion Harry Kane has reached four goals for the Premier League season after his recent strike at Southampton, but still needs an incredible second half of the campaign to make a meaningful impact on the standings.
2021/22 EPL top goalscorers
Who are the past winners of the Premier League Golden Boot?
EPL Golden Boot winners
The record for most goals in a season is shared by Alan Shearer (1994/95) and Andy Cole (1993/94).
Both players scored an astonishing 34 goals, though the season was longer then – Shearer did it in 42 matches and Cole in 40.
The Golden Boot winner with the best goals per game ratio in a season is Harry Kane.
England’s captain netted 29 times in just 30 games to win the 2016/17 title, averaging 0.97 goals per game.
There are only three players who have scored the most goals in the EPL more than twice.
Shearer won the Golden Boot three times, once with Newcastle and twice with Blackburn Rovers, while Kane’s win in 2020/21 was also his third.
Cristiano Ronaldo and Luis Suarez have both won the award, scoring 31 goals in 2007/08 and 2013/14 respectively.
The Premier League began from the 1992/93 season.
Prior to that, Ian Wright was the last highest goalscorer in England when it was the old First Division.
Gary Lineker and Alan Smith were also winners in the 1990s before the league was rebranded.
Who are the Premier League top scorers of all time?
Alan Shearer is the highest goalscorer in Premier League history, having ended his career in 2006 with a magnificent 260 goals to his name in England’s top division.
Man Utd legend Wayne Rooney (208) is the only other player who has scored more than 200 EPL goals.
Andy Cole (187), Sergio Aguero (184), Frank Lampard (177) and Thierry Henry (175) are other former Premier League players who sit near the top of the all-time list.
Kane is the highest-scoring active player and had 166 goals when he started this season.
He has long been cited as one of the rare contenders who has a chance to rival Shearer’s record total.
Robbie Fowler (163), Jermain Defoe (162) and Michael Owen (150) round out the 10 players in EPL history who have scored 150 goals or more.